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As the our number 1 purpose, differences in the characteristics of outcomes between female and male sex were analysed

New endpoints Operating-system, AFS, and you will liberty from amputation was indeed analysed having fun with multivariable day-based Cox regression models from inside the the full model (the people) and with sex-communication terminology for each and every risk grounds. The brand new models getting freedom regarding amputation believed demise while the a contending risk in contrast to the new AFS habits, which included dying about endpoint. For this specific purpose, we made use of Good and you will Gray's method of estimate sandwich-distributional threat ratios (HRs) regarding the AFS design.

The models included risk profiles of patients at baseline and additionally time-dependent occurrence of comorbidities or procedures in the follow-up period.

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